Cialis Information -
the following Cialis information section addresses the most common
questions associated with the use of Cialis for erection enhancement:
What is Cialis?
Cialis represents
the longest lasting erectile enhancement drug on the market today.
Cialis enhances erections up to 36 hours following a single dose.
Cialis has been approved by the European Commission for the treatment of
erectile dysfunction and is now available throughout Europe.
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Why is Cialis sometimes referred to as tadalafil?
Tadalafil is the
generic name for Cialis. The generic name represents the medications
nonproprietary or chemical name, whereas, the brand name is the name a
pharmaceutical give to a medication for marketing purposes.
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What is the appropriate dose of Cialis?
During clinical
testing Cialis was administered in 10mg or 20mg doses. For most men the
10mg dose is sufficient to substantially enhance erections. Most
doctors, concur buy the Cialis 20mg dose and split the tablet in half
taking just 10mg of Cialis. Lilly pharmaceuticals charges the same price
for both the Cialis 20mg tablets and the 10mg tablets.
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What are the results of the clinical trials
concerning the percentage of men who had improved erections while taking
Cialis?
The Phase III
study examined the safety and efficacy of "on-demand" Cialis treatment
in 196 men suffering from mild-to-severe ED(1). Men in the study were
randomized to receive up to 20 mg of Cialis or placebo over a 12-week
period. Men were free to take their study medication without
restrictions on food or alcohol consumption and to have sex with their
partners at the time of their choosing after each dose.
Results showed
that 95 percent of men taking Cialis 10 mg reported significantly
improved erections compared with baseline. In addition, 78 percent of
intercourse attempts recorded by all men on Cialis 10 mg were
successful. Importantly, 68 percent of men with ED treated with Cialis
10 mg achieved an erectile function score experts consider "normal" for
healthy men as measured by the International Index of Erectile Function
(IIEF).
On the 10 mg dose,
92 percent of men reported improved erections, and 90 percent of
intercourse attempts were successful. Forty-two percent of men taking
the 10 mg dose achieved IIEF scores in the normal range. Fifty-four
percent of patients on placebo in the study reported improved erections,
while 43 percent of their attempts were successful. Twenty percent of
men taking placebo (sugar pill) attained IIEF scores in the "normal"
range.
In this study,
side effects were mild to moderate, and their incidence diminished with
continued treatment. The most commonly reported side effects were
backache, muscle ache and upset stomach. There were no clinically
significant changes in blood pressure, heart rate, electrocardiograms or
laboratory tests attributable to treatment with Cialis.
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How long does it take to notice the effects of
Cialis once I take the medication?
During clinical
studies most men were able to achieve an erection within twenty minutes
of taking Cialis.
How long does the effects of Cialis last?
In a Phase III
clinical study designed to evaluate the efficacy of Cialis at specific
time points after dosing, 348 men with mild-to-severe ED were randomly
assigned to receive Cialis 10 mg (n=175) or placebo (n=173) over
approximately an eight-week period. Patients were instructed to attempt
intercourse with their partners on four specific occasions: on two
occasions at 24 hours after dosing and on two occasions at 36 hours
after dosing. The primary endpoint was the percentage of successful
sexual intercourse attempts.
"Cialis was
statistically superior to placebo in enabling men with ED to have
successful intercourse at 24 or 36 hours after taking the drug and
showed a consistent effect at both time points," said Raymond Rosen,
Ph.D., study author and director of the Program in Human Sexuality.
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How does Cialis work?
In technical terms
Cialis exerts its action by effecting two enzymes, Cyclic guanosine
monophosphate (cGMP) and phosphodiesterase type 5 (PDE5) that play
important roles in erectile function. Sexual stimulation triggers the
local release of nitric oxide (NO) from nerves and endothelial cells in
the penis. NO stimulates an enzyme that catalyzes formation of cGMP from
the nucleotide guanosine 5-triphospate (GTP) in the penile blood vessels
and corpus cavernosum walls.
The cGMP causes
vasodilation of arteries, allowing the influx of blood into the corpus
cavernosum. Increased blood flow into the penis causes the erectile
tissue to expand. When the erectile tissue has expanded sufficiently,
the veins draining the corpus cavernosum become compressed. This
decreases the outflow of blood from the penis, and the blood remains in
the corpus cavernosum to keep the penis erect.
The enzyme PDE5
eventually causes degradation of the cGMP, and the erection ends.
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How much time must surpass before Cialis is
effective?
Cialis is rapidly
absorbed. Most patients in clinical trial reported that Cialis produced
positive effects within twenty minutes.
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What are the precautions/warnings concerning
Cialis?
Men who are taking medicines that contain nitrates (Nitroglycerin) of
any kind must never use Cialis. Patients should not take Cialis even if
you only take nitroglycerin medication occasionally. There is also a
potential for cardiac risk during sexual activity in patients with
preexisting cardiovascular disease. Therefore, Cialis should not be used
in men where sexual activity is inadvisable because of their underlying
cardiovascular status. Individuals should inform their physician
concerning all medications they are taking, including those medications
acquired by a prescription as well as over the counter medicines. The
use of Cialis offers no protection against sexually transmitted
diseases, including HIV. Patients should continue to use protective
measures necessary to guard against these diseases. In case of an
overdose, call your physician immediately.
Why is Cialis absolutely contraindicated in
individuals who are currently taking medications containing nitrates?
Cialis may increase the hypotensive effects of nitrates to life
threatening levels. Therefore, individuals who are currently using
nitrates in any form even intermittently should not take Cialis.
Nitrates are available in many medications; sprays, ointments, skin
patches, pastes and tablets dissolved in the mouth. Nitrates are also
found in illicit drugs such as amyl nitrate or nitrite "Poppers". If you
are unsure if you are currently taking nitrates please value your health
and consult with your local physician or pharmacist.
Can I use Cialis with other medications?
Yes, it is
generally safe to use Cialis while on other medications, however some
medicines may increase the effects of Cialis. Individuals should always
consult with their healthcare provider prior to taking any medication.
Note Cialis does have one absolute contraindication; individuals who are
taking medication-containing nitrates (even intermittently) should not
take Cialis.
Can I get Cialis over the counter?
No, Cialis should
only be taken by prescription from a licensed physician. Regulations do
not permit Cialis to be taken without prescription. Secondary to the
advent of the internet individuals may now order Cialis online simply by
completing an online medical questionnaire. Subsequently, a licensed
physician will review your medical history and patient profile. If
approved for a Cialis prescription, your order shipped discreetly to
your home or office in 1-2 business days.
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